Click here for more information about Algenuity
Click here for more information about Liqofluxphenometrics515R1
Visit cricatalyst.com!Evodos Separation Technology

Technology

GeneArt Precision TALs

March 21, 2012
AlgaeIndustryMagazine.com

TALE proteins offer precise gene editing capabilities.

TALE proteins offer precise gene editing capabilities.

Life Technologies has announced the launch of GeneArt® Precision TALs, generally referred to as TAL effector proteins (TALE), which will allow researchers in healthcare, agriculture and energy the ability to edit genomes and control gene activity with unprecedented precision and reliability.

Specific applications range from design of disease and drug efficacy models for the pharmaceutical industry to human gene therapy, a field that has been plagued by safety concerns due to random insertion of introduced genes and vectors into the genome.

TAL effectors can be designed to bind to specific DNA sequences selected by researchers and can deliver a variety of functional elements to activate or repress gene expression or to cut and insert DNA with precision. TAL proteins have an advantage over competing zinc finger technology in that they are simpler to design and bind with greater specificity, displaying fewer “off-target” events.

TAL effectors were originally discovered in bacteria that infect plants, where they target specific DNA sequences in the plant genome, rewiring gene expression to establish and propagate infection. The simple TAL effector translation code allows researchers to specifically design TAL binding proteins to bind to a DNA sequence of choice.

“Researchers give us the sequence they want to target, and we send them a gene encoding the TAL protein that will target it,” said Nathan Wood, vice president of synthetic biology at Life Technologies.

GeneArt® Precision TALs are supplied as Gateway® compatible entry clones encoding a DNA binding protein for a specific customer-submitted sequence fused to a range of customer selected effector domains. Custom TALs will typically be delivered in 3 weeks after orders are placed.

The current offering includes TALs fused with gene activators, endonucleases or a vector with multiple cloning sites providing customers the ability to link their own functional domain proteins to the TAL protein, constituting a system that is easily customized to each researcher’s needs. A TAL offering with a gene repression domain will be released at a future date.

More Like This…

HOME A.I.M. Archives

Copyright ©2010-2017 AlgaeIndustryMagazine.com. All rights reserved. Permission required to reprint this article in its entirety. Must include copyright statement and live hyperlinks. Contact editorial@algaeindustrymagazine.com. A.I.M. accepts unsolicited manuscripts for consideration, and takes no responsibility for the validity of claims made in submitted editorial.

twittertopbarlinks_eventstopbarlinks_requesttopbarlinks_archives

From The A.I.M. Archives

— Refresh Page for More Choices
The GNT Group, a market leader in using algae as natural ingredients for color, has begun construction of an additional spirulina plant at its headquarters in Mierlo, the...
Kuo Chia-erh reports for Taipei Times that Taiwan Cement Corp, the nation’s leading cement supplier, has announced plans to expand its microalgae farm, which produces ast...
Jason Smith reports for undercurrentnews that Kentucky-based Alltech is willing to invest in overseas algae production plants closer to its feed customers if demand for i...
An unprecedented harmful algal bloom off the coast of New England this fall provided a unique opportunity for Waterville, Maine-based Colby College students studying at B...
Fraunhofer-Gesellschaft reports in Science Daily that two algae species survived 16 months on the exterior of the International Space Station (ISS) despite extreme temper...
Kailua-Kona, Hawaii-based Cellana, Inc., a leading developer of algae-based products for sustainable nutrition and energy applications, and Living Ink Technologies of Den...
PhysOrg reports that recent efforts have been made by researchers in Japan to reduce the cost of biodiesel production by using pulsed electric fields (PEF) to extract hyd...
Diane Stopyra writes in Salon.com that a growing number of coastal states around the country are undertaking large-scale seaweed farming projects. While farms are underwa...
Carl Zimmer writes in The New York Times about a team of Australian scientists studying how climate change will alter ecosystems – by using miniature ecosystems, called m...
ExxonMobil and Synthetic Genomics Inc. have announced that, in joint research into advanced biofuels, they have modified an algal strain to more than double its oil conte...
The United States Department of Energy (DOE) announced that the University of New England was awarded a three-year, nationally competitive research grant for $1,321,039 f...
Malaysia-based Algaetech International, a pioneer algae technology company specializing in R&D, as well as production and commercialization of algae-derived high ...