Click here for more information about Algenuity
Click here for more information about Liqofluxphenometrics515R1
Visit cricatalyst.com!Evodos Separation Technology

Technology

GeneArt Precision TALs

March 21, 2012
AlgaeIndustryMagazine.com

TALE proteins offer precise gene editing capabilities.

TALE proteins offer precise gene editing capabilities.

Life Technologies has announced the launch of GeneArt® Precision TALs, generally referred to as TAL effector proteins (TALE), which will allow researchers in healthcare, agriculture and energy the ability to edit genomes and control gene activity with unprecedented precision and reliability.

Specific applications range from design of disease and drug efficacy models for the pharmaceutical industry to human gene therapy, a field that has been plagued by safety concerns due to random insertion of introduced genes and vectors into the genome.

TAL effectors can be designed to bind to specific DNA sequences selected by researchers and can deliver a variety of functional elements to activate or repress gene expression or to cut and insert DNA with precision. TAL proteins have an advantage over competing zinc finger technology in that they are simpler to design and bind with greater specificity, displaying fewer “off-target” events.

TAL effectors were originally discovered in bacteria that infect plants, where they target specific DNA sequences in the plant genome, rewiring gene expression to establish and propagate infection. The simple TAL effector translation code allows researchers to specifically design TAL binding proteins to bind to a DNA sequence of choice.

“Researchers give us the sequence they want to target, and we send them a gene encoding the TAL protein that will target it,” said Nathan Wood, vice president of synthetic biology at Life Technologies.

GeneArt® Precision TALs are supplied as Gateway® compatible entry clones encoding a DNA binding protein for a specific customer-submitted sequence fused to a range of customer selected effector domains. Custom TALs will typically be delivered in 3 weeks after orders are placed.

The current offering includes TALs fused with gene activators, endonucleases or a vector with multiple cloning sites providing customers the ability to link their own functional domain proteins to the TAL protein, constituting a system that is easily customized to each researcher’s needs. A TAL offering with a gene repression domain will be released at a future date.

More Like This…

HOME A.I.M. Archives

Copyright ©2010-2017 AlgaeIndustryMagazine.com. All rights reserved. Permission required to reprint this article in its entirety. Must include copyright statement and live hyperlinks. Contact editorial@algaeindustrymagazine.com. A.I.M. accepts unsolicited manuscripts for consideration, and takes no responsibility for the validity of claims made in submitted editorial.

twittertopbarlinks_eventstopbarlinks_requesttopbarlinks_archives

From The A.I.M. Archives

— Refresh Page for More Choices
Bioenergy-news.com reports that Volkswagen showcased its algae biogas-powered vehicle at a biogas project based in El Torno Chiclana, a town in south-west Spain. The test...
San Francisco biotech startup New Wave Foods aims to address the impact of overfishing, bycatch, water pollution, slave labor, an animal death toll in the trillions, and ...
Natural Icelandic astaxanthin supplier, ArcticFarma, has reached an agreement with a subsidiary of China-based BGG to rename itself in order to avoid market confusion. “B...
The water sample taken from the St. Lucie River near the coastline of Ft. Pierce, Florida was loaded with blue-green algae when it arrived in Ben Spaulding’s lab in Scarb...
Stavanger, Norway-based Skretting, a 100+ year-old leader in the manufacture and supply of aquaculture feeds for fish and shrimp, has announced that they are now offering...
Forbes is running an interview with Bren Smith, an Ashoka Fellow and the founder of GreenWave, an organization dedicated to restoring oceans, mitigating climate change an...
Algatechnologies Ltd (Algatech), of Kibbutz Ketura, Israel, has become part of the FoodConnects consortium, as winner of a pan-European competition for the Food4Future pr...
For algal biofuels to compete with petroleum, farming algae has to become less expensive. Toward that goal, Sandia National Laboratories is testing strains of algae for r...
WesTech Engineering, Inc. and Utah State University’s Sustainable Waste-to-Bioproducts Engineering Center (SWBEC) are jointly engaged in developing processes for more eff...
David Erickson writes in the (Montana) Missoulian that Clearas Water Recovery, a Missoula tech company formed eight years ago, has developed a patented process to use alg...
The recent announcement by the U.S. Department of Energy (DOE) of three projects to receive up to $8 million, aimed at reducing the costs of producing algal biofuels and ...
Adoption of advanced technologies in various stages of natural astaxanthin production, such as microalgae harvesting, cultivation, extraction, and drying, have been major...