Click here for more information about Algenuity
Click here for more information about Liqofluxphenometrics515R1
Visit cricatalyst.com!Evodos Separation Technology

Research

Enzyme could help accelerate algal biofuel production

August 20, 2018
AlgaeIndustryMagazine.com

The red alga C. merolae grown in culture in the laboratory. Credit: Sousuke Imamura

Researchers at Tokyo Institute of Technology have homed in on an enzyme belonging to the glycerol-3-phosphate acyltransferase (GPAT) family as a promising target for increasing biofuel production from the red alga Cyanidioschyzon merolae.

Algae are known to store up large amounts of oils called triacylglycerols (TAGs) under adverse conditions such as nitrogen deprivation. Understanding precisely how they do so is of key interest to the biotechnology sector, as TAGs can be converted to biodiesel. To this end, scientists are investigating the unicellular red alga C. merolae as a model organism for exploring how to improve TAG production.

A study led by Sousuke Imamura at the Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology (Tokyo Tech), has now shown that an enzyme called GPAT1 plays an important role in TAG accumulation in C. merolae even under normal growth conditions – that is, without the need to induce stress.

Remarkably, the team demonstrated that TAG productivity could be increased by more than 56 times in a C. merolae strain overexpressing GPAT1 compared with the control strain, without any negative effects on algal growth.

Their findings, published in Scientific Reports, follow up previous research by Dr. Imamura and others that had suggested two GPATs, GPAT1 and GPAT2, may be closely involved in TAG accumulation in C. merolae.

“Our results indicate that the reaction catalyzed by the GPAT1 is a rate-limiting step for TAG synthesis in C. merolae, and would be a potential target for improvement of TAG productivity in microalgae,” the researchers say.

The team plans to continue exploring how GPAT1 and GPAT2 might both be involved in TAG accumulation. An important next step will be to identify transcription factors that control the expression of individual genes of interest.

“If we can identify such regulators and modify their function, TAG productivity will be further improved because transcription factors affect the expression of a wide range of genes including GPAT1-related genes,” they say. “This kind of approach based on the fundamental molecular mechanism of TAG synthesis should lead to successful commercial biofuel production using microalgae.”

Read More

More Like This…

Copyright ©2010-2019 AlgaeIndustryMagazine.com. All rights reserved. Permission required to reprint this article in its entirety. Must include copyright statement and live hyperlinks. Contact editorial@algaeindustrymagazine.com. A.I.M. accepts unsolicited manuscripts for consideration, and takes no responsibility for the validity of claims made in submitted editorial.

twittertopbarlinks_eventstopbarlinks_requesttopbarlinks_archives

From The A.I.M. Archives

— Refresh Page for More Choices
Trade Arabia reports that the Oman Centre for Marine Biotechnology (OCMB) recently signed a memorandum of understanding with Swedish Algae Factory to support the domestic...
42 Technology has been appointed by LabXero, acoustic particle filtration technology company, to help develop pilot-scale biomanufacturing equipment that could significan...
Cody Nelson writes for MPRNews.org that a team of University of Minnesota-Duluth researchers wanted to know how shortening winters — and less ice cover on lakes — might i...
French researchers have been exploring the potential of algae for boosting the immune systems of animals and reducing the use of antibiotics in livestock farming. Past st...
Israeli-based Algatechnologies, Ltd. (Algatech), is teaming up with the Italian R&D company, Sphera Encapsulation S.r.l (Sphera), to develop innovative functional ingredi...
Amy Thompson writes in Space.com that SpaceX successfully launched its 15th Space Station cargo-resupply mission on Friday, June 29; carrying a payload of experiments des...
Sophie Kevany writes in Decanter.com that a group of vineyards in France’s Bordeaux and Cognac regions are exploring whether algae can be used to prevent the fungal infec...
San Diego, CA and Kailua-Kona, HI-based Cellana, Inc. has signed an Asset Purchase Agreement with Cyanotech Corporation for the sale of Cellana’s six-acre production and ...
E.A. Crunden writes in thinkprogress.org that Florida’s first gubernatorial debate was dominated by environmental and climate issues, with an emphasis on the state’s alga...
London-based architectural and urban design firm ecoLogicStudio www.ecologicstudio.com, led by Claudia Pasquero and Marco Poletto, has unveiled Photo.Synth.Etica, a large...
Steve Fountain writes in fortstocktonpioneer.com that, amid the 800-page law that last month set the country’s farm policy through 2023, is the expansion of federal suppo...
Jessica D'Lima writes in AdvancedScienceNews.com that medicine is moving towards minimally invasive procedures, which have important patient-oriented benefits such as sho...